Triangle showing the relation of the laboratory themes and health and disease  

 

A laboratory at the Forsyth Institute,

Boston, MA

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PUBLICATIONS

Jacques Izard, Christian Renken, Chyong-Ere Hsieh, Daniel C. Desrosiers, Star Dunham-Ems, Carson La Vake, Linda L. Gebhardt, Ronald J. Limberger, David L. Cox, Michael Marko, and Justin Radolf.
Cryo-electron tomography elucidates the molecular architecture of Treponema pallidum, the syphilis spirochete.
Journal of Bacteriology (2009) vol. 191 (24), pp. 7566-7580 (Cover) (Press release).

Paolo Gaibani, Caterina Vocale, Simone Ambretti, Francesca Cavrini, Jacques Izard, Luisa Miragliotta, Maria Teresa Pellegrino and Vittorio Sambri.
Killing of Treponema denticola by mouse peritoneal macrophages.
Journal of Dental Research (2010).In press.

The Forsyth Metagenomic Support Consortium and Jacques Izard*.
Building the genomic base-layer of the oral “omic” world.
Book Chapter in: Interface Oral Health Science 2009. Springer Japan (2010). In press.

Julia Downes, Sonia Vartoukian, Floyd E. Dewhirst, Jacques Izard, Tsute Chen, Wenhan Yu, Iain C. Sutcliffe and William G. Wade.
Pyramidobacter pisciolens gen. nov., sp. nov., a member of the phylum ‘Synergistetes’ isolated from the human oral cavity.
International Journal of Systematic and Evolutionary Microbiology (2009) vol. 59 pp. 972-980.
DOI 10.1099/ijs.0.000364-0.

Jacques Izard*, Chyong-Ere Hsieh, Ronald J. Limberger, Carmen A. Mannella and Mike Marko.
Native cellular architecture of Treponema denticola revealed by cryo-electron tomography.
Journal of Structural Biology (2008). Vol.163 (1) pp. 10-17.
[abstract]

Jacques Izard*.
Cytoskeletal cytoplasmic filament ribbon of Treponema: a member of an intermediate-like filament protein family.
Journal of Molecular Microbiology and Biotechnology (2006). Vol. 11 pp. 159-166.

Federico Foschi, Jacques Izard, Hajime Sasaki, Victorio Sambri, Carlo Prati, Ralph Müller, and Philip Stashenko.
Treponema denticola in disseminating endodontic infections. (Cover)
Journal of Dental Research (2006). vol. 85 (8) pp.761-765 .

Jacques Izard, and Ronald J. Limberger.
Structural and genomic features of treponemal architecture.
Book Chapter in: Treponema molecular and cellular biology.
J. Radolf and S.A. Lukehart (ed.) Horizon Bioscience (2006). ISBN 1-904455-10-7 .
[To get a complete description and to buy the book from Caister Academic Press, click here]

Anne C. R. Tanner and Jacques Izard.
Tannerella forsythia, a periodontal pathogen entering the genomic era.
Periodontology 2000 (2006). vol. 42 pp. 88-113.

Jacques Izard*, Chyongere-E. Hsieh, Carmen A. Mannella, Ronald J. Limberger, and Mike Marko.
Periplasm organization in Treponema denticola as studied by cryo-electron tomography.
Microscopy and Microanalysis (2005) vol. 11 (Suppl 2) pp340-341.

Anne C. R. Tanner and Jacques Izard.
Etiology of oral disease in view of microbial complexity.
Oral Biosciences & Medicine (2005) vol.2 n. 2/3 pp. 209-213.

Linda Slivienski-Gebhardt, Jacques Izard, William A. Samsonoff, and Ronald J. Limberger.
Development of a novel chloramphenicol-resistance expression plasmid used for genetic complementation of a fliG-deletion mutant of Treponema denticola.
Infection Immunity (2004), vol. 72(9) pp. 5493-5497.

Jacques Izard*, Bruce F. McEwen, Rita M. Barnard, Thomas Portuese, and Ronald J. Limberger.
Tomographic reconstruction of treponemal cytoplasmic filaments reveals novel bridging and anchoring components.
Molecular Microbiology.(2004) vol. 51 (3) pp. 609-618.
[extra material (movie)]

Jacques Izard*, and Ronald J. Limberger.
Rapid Screening Method for Quantitation of Bacterial Lipids from Whole Cells.
Doi: 10.1016/S0167-7012(03)00193-3..
Journal of Microbiological Methods. (2003) vol. 55 n. 2, pp. 411-418.

Jacques Izard* and Ronald J. Limberger.
Pleiotropic Defects in a Treponema denticola Cytoplasmic Filament Mutant.
Journal of Bacteriology (2001) vol. 183 n. 3 pp. 1078-1084.

Jacques Izard*, William. A. Samsonoff, Mary-Beth Coy and Ronald J. Limberger.
Genetic and Structural Analysis of the Cytoplasmic Filaments of Wild-type and a Flagella Filament-deficient Isolate of Treponema phagedenis.
Journal of Bacteriology (1999) vol. 181 n. 21 pp. 6739-6746.

Ronald J. Limberger, Linda L. Slivienski, Jacques Izard and William A. Samsonoff.
Insertional Inactivation of Treponema denticola tap1 Results in a Non-Motile Mutant with Elongated Flagellar Hooks.
Journal of Bacteriology (1999) vol. 181 n. 12 pp. 3743-3750.

Denis Duché, Jacques Izard, Juan M. Gonzalez-Mañas, Michael W. Parker, Martine Chartier and Daniel Baty.
Two Disulfide Bonds Introduced in the Colicin A Pore-forming Domain Block the in vivo but not the in vitro Toxin Activity.
Journal of Biological Chemistry (1996) vol. 271 n°26, pp. 15401-15406.
[abstract]

Rita Vos and Yves Engelborghs; Jacques Izard and Daniel Baty.
Fluorescence Study of the Three Tryptophan Residues of the Pore-forming Domain of Colicin A Using Multifrequency Phase Fluorometry.
Biochemistry (1995) vol. 34, pp. 1734-1743.

Jacques Izard, Michael W. Parker, Martine Chartier, Denis Duché and Daniel Baty. A Single Amino Acid Substitution Can Restore the Solubility of Aggregated Colicin A Mutants in Escherichia coli.
Protein Engineering (1994) vol. 7 n°12, pp. 1495-1500.
[Protein Engineering has been relauched in 2004 as Protein Engineering, Design and Selection]

 
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